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These common interactions involve two salt bridges with E 6.53b and E/D 7.42b (via the positively charged N-terminal nitrogen atom of Y1 P ), stacking interactions with W39 GLP-1R /W39 GIPR /W36 GCGR (via F22 P ), Y 1.43b (via F6 P ) and W 5.36b (via Y1 P ), multiple hydrogen bonds with L32 GLP-1R /A32 GIPR /M29 GCGR (via D15 P ), Y 1.43b (via Q3 P ), Y 1.47b (via Q3 P ), T/E 45.52b (via S11 P ) and N300 GLP-1R /N290 GIPR /N298 GCGR (via S8 P ), along with extensive hydrophobic contacts with L/Y 1.36b (via Y10 P and MeL13 P ), I/V 3.40b (via Y1 P ), W 5.36b (via G4 P ), L 7.39b and I/L 7.43b (via Aib2 P )

Presented for research literature review only Ito T et al

Lyophilized (powder) GHK-Cu remains stable refrigerated for extended periods

Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute

Second, peptide bonds are substrates for skin-surface peptidases

Note: Always consult a medical professional before beginning any new therapy